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The Arndtsen and Lumb research groups jointly report a copper-catalyzed aerobic oxidation of alcohols without the use of traditional N-oxide co-oxidants. The tyrosinase inspired Cu-diamine complex efficiently mediates the oxidation of both activated and un-activated alcohols at ambient pressure and temperature. Our catalyst proceeds through a different mechanistic pathway with regards to traditional systems and as result, demonstrates complementary chemoselectivity to existing methods.聽 This work was recently published in .